منابع مشابه
Forbidden synonymous substitutions in coding regions.
In the evolution of highly conserved genes, a few "synonymous" substitutions at third bases that would not alter the protein sequence are forbidden or very rare, presumably as a result of functional requirements of the gene or the messenger RNA. Another 10% or 20% of codons are significantly less variable by synonymous substitution than are the majority of codons. The changes that occur at the ...
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We give an automatic method to generate transition matrices associated with twodimensional contraints of finite type by using squared substitutions of constant dimension.
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We discuss a model for the evolutionary distance between two coding DNA sequences which specializes to the DNA/protein model proposed in Hein [3]. We discuss the DNA/protein model in details and present a quadratic time algorithm that computes an optimal alignment of two coding DNA sequences in the model under the assumption of affine gap cost. The algorithm solves a conjecture in [3] and we be...
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DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...
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objective: mitochondrial dna (mtdna) is a useful tool for population studies, identification of humans and forensic dna studies. the existence of several hundreds copies of mtdna per cell permit its extraction from minute or degraded samples. in addition, the level of polymorphism in the hypervariable (hv) region is high enough to permit its use in human identity testing. however, the presence ...
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ژورنال
عنوان ژورنال: Nature
سال: 1997
ISSN: 0028-0836,1476-4687
DOI: 10.1038/385111b0